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Both IFN and TNF blockers seem to be effective in the management of ocular and extraocular manifestations of Behçet disease.

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Because uric acid is created during the digestion and breakdown of purines, patients can reduce the concentration of uric acid in the blood by avoiding high-purine foods such as anchovies, asparagus, dried beans and peas, mushrooms and organ meats (such as livers and kidneys).


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Among the affected joints are finger joints, the joint at the base of the thumb and the joint at the base of the big toe.

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Pregnancy and breast-feeding: Colchicine has been shown to cause harm to the fetus.

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Early phase: nausea, vomiting (emesis), abdominal pain, and increased salivation; fluid build-up in the airways (bronchorrhea); rapid, heavy breathing (hyperpnea); high blood pressure (hypertension), rapid heart rate (tachycardia), and generalized narrowing of the blood vessels (vasoconstriction) with pale skin; and headache, dizziness, confusion, agitation, restlessness, loss of balance and difficulty walking, and visual and hearing (auditory) distortions.

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Most studies have found no significant side effects at the doses used for up to 6 months.

Our study suggests that colchicine may be useful in avoiding recurrence of pericarditis, although these results need to be confirmed in a larger, double-blind study.

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Avoid driving or performing hazardous tasks for the first 24 hours after taking this medicine or when the dose is increased.

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Check with your physician if you have any questions.

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This article stresses the importance of renal insufficiency as a risk factor in allopurinol hypersensitivity, and the importance of reducing allopurinol dose in patients with renal insufficiency and of making sure that only patients who meet appropriate criteria get treated with allopurinol.

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ALLOPURINOL (Zyloprim -- a prescription drug) inhibits uric acid synthesis and has been linked to skin eruptions, inflammation of the blood vessels, and liver toxicity.

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However the individual in question had many tests on his uric acid level of a period of 12 years, and they were never higher than 375 µmol per litre, and often much lower.

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